GWAS of macro-scale resting state functional brain networks identify shared biology with brain structure and autism
View ORCID ProfileYuankai He, Rafael Romero-Garcia, Bin Wan, Jakob Grove, Anders D. Børglum, Simon Baron-Cohen, Sofie L. Valk, Edward T. Bullmore, Richard A.I. Bethlehem, Varun Warrier
doi: https://doi.org/10.1101/2025.04.27.25326490
Yuankai He
1Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, CB2 3EB, Cambridge, UK
Rafael Romero-Garcia
1Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, CB2 3EB, Cambridge, UK
2Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Dpto. de Fisiología Médica y Biofísica, Sevilla, Spain
Bin Wan
3Institute of Neuroscience and Medicine (INM-7: Brain and Behavior), Research Center Jülich, Jülich, Germany
4Max-Planck-Institut für Kognitions-und Neurowissenschaften, Stephanstraße 1a, 04103 Leipzig, Germany
5University Hospitals of Geneva, Geneva, Switzerland
Jakob Grove
6The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 8010, Denmark
7Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, 8000, Denmark
8Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, 8000, Denmark
9Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark, 8000
Anders D. Børglum
6The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 8010, Denmark
7Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, 8000, Denmark
8Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, 8000, Denmark
Simon Baron-Cohen
1Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, CB2 3EB, Cambridge, UK
Sofie L. Valk
3Institute of Neuroscience and Medicine (INM-7: Brain and Behavior), Research Center Jülich, Jülich, Germany
4Max-Planck-Institut für Kognitions-und Neurowissenschaften, Stephanstraße 1a, 04103 Leipzig, Germany
Edward T. Bullmore
1Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, CB2 3EB, Cambridge, UK
Richard A.I. Bethlehem
10Department of Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
Varun Warrier
1Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, CB2 3EB, Cambridge, UK

Data Availability
All GWAS summary statistics for graph phenotypes will be made publicly accessible on University of Cambridge servers upon publication. Summary statistics for autism can be requested from Jakob Grove. Summary statistics for other neuropsychiatric conditions have been made publicly available through the relevant articles listed in Supplementary Table 5. Please refer to the data availability sections of the respective articles.
Posted April 28, 2025.
GWAS of macro-scale resting state functional brain networks identify shared biology with brain structure and autism
Yuankai He, Rafael Romero-Garcia, Bin Wan, Jakob Grove, Anders D. Børglum, Simon Baron-Cohen, Sofie L. Valk, Edward T. Bullmore, Richard A.I. Bethlehem, Varun Warrier
medRxiv 2025.04.27.25326490; doi: https://doi.org/10.1101/2025.04.27.25326490
GWAS of macro-scale resting state functional brain networks identify shared biology with brain structure and autism
Yuankai He, Rafael Romero-Garcia, Bin Wan, Jakob Grove, Anders D. Børglum, Simon Baron-Cohen, Sofie L. Valk, Edward T. Bullmore, Richard A.I. Bethlehem, Varun Warrier
medRxiv 2025.04.27.25326490; doi: https://doi.org/10.1101/2025.04.27.25326490
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